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VIBATIV is indicated for treatment of adult patients with complicated skin and skin structure infections (cSSSI) caused by susceptible isolates of the following Gram-positive microorganisms such as staphylococcus aureus (including methicillin-susceptible and -resistant isolate), Streptococcus agalactia, and Enterococcus faecalis (vancomycin-susceptible isolates only).

Combination therapy may be clinically indicated if the documented or presumed pathogens include gram-negative organisms.

Vibative Dosage

• VIBATIV is dosed once-daily with no therapeutic drug monitoring required.
• 10 mg/kg of VIBATIV should be administered over a 60-minute period in patients ≥18 years of age by IV infusion once every 24 hours for 7 to 14 days.
• Duration of therapy should be guided by the severity and site of the infection and the patient’s clinical and bacteriological progress.

Vebativ Side Effects and Reactions
The most common adverse reactions (≥10% of patients treated with VIBATIV) observed in the Phase III cSSSI clinical trials were taste disturbance, nausea, vomiting, and foamy urine.

In the Phase III cSSSI clinical trials, serious adverse events were reported in 7% of patients treated with VIBATIV and most commonly included renal, respiratory, or cardiac events. In the same trials, serious adverse events were reported in 5% of vancomycin-treated patients, and most commonly included cardiac, respiratory, or infectious events. Eight deaths were reported in each treatment group.