Tramadol – Benefits, dosage, side effects

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Tramadol is one of the strongest painkillers used to treat moderate to severe pain (eg pain after surgery). Tramadol works by influencing chemical reactions in the brain and nervous system which ultimately reduce the pain sensation.

Trademarks: Contram 50, Orasic, Tradosik, Tramofal, Dolgesik, Radol, Tramal

About Tramadol

Opioate Analgesic Group

Prescription Drug Category

Benefits Relieve moderate to severe pain

Consumed by adults and children over the age of 12 years

Categories of pregnancy and lactation
Category C: Studies in animal studies have shown adverse effects on the fetus, but there have been no controlled studies in pregnant women. The drug should only be used if the expected amount of benefit exceeds the risk to the fetus.

Forms of drugs Capsules, tablets, soluble drugs, injections.


  1. Do not take tramadol more than 400 mg per day.
  2. For users aged 75 years and over, the maximum dose per day is 300 mg.
  3. Tramadol should not be given to children under the age of 17 because it can cause severe side effects, although it is rare, namely difficulty breathing.
  4. Please be careful of people with kidney, liver, prostate, respiratory, adrenal gland, thyroid, epilepsy, hypotension (low blood pressure), constipation, intestinal inflammation, myastenia gravis, bile duct disorders, or if you have just had a severe head injury.
  5. Keep in mind that there are several types of drugs that contain tramadol, but not 100 percent. Be sure to read the ingredients contained in each drug. Avoid consuming two or more drugs that contain tramadol simultaneously to avoid overdose
  6. Be aware of the use of tramadol in people with drug or alcohol dependence.
    If an allergic reaction or overdose occurs, contact a doctor immediately.

Doses of Tramadol
The dose of tramadol depends on the severity of the pain felt by the patient. However, consumption of this drug should not exceed 400 mg per day.

To reduce pain quickly

Dosage and Frequency
50-100 mg per 4-6 hours

The use of tramadol doses for a longer period of time will be arranged by the doctor according to the health conditions and the development of the patient’s recovery. For children under 12 years, the dosage and use of tramadol will be adjusted. Meanwhile, for seniors over 75 years, it is recommended not to consume tramadol more than 300 mg per day.

Take Tramadol Properly
Tramadol can be used before or after meals, and should be used only when pain starts to appear.

Use Tramadol immediately to replace the missed usage schedule if it pauses with the next schedule not too close. But if the rest is near, ignore it and don’t double the dose.

Do not exceed the dosage and duration of use determined by the doctor because it can cause dependence. Termination of use of this drug must be done in stages, according to the doctor’s instructions.

During taking Tramadol, patients are advised to avoid liquor and drugs that can have an impact on the level of consciousness (eg antihistamines and sedatives).

During treatment with tramadol, it is recommended not to drive a vehicle or operate heavy machinery to avoid accidents.

Drug Interactions
The following are some of the risks that may occur if using tramadol together with certain drugs, including:

  • Increases the potential for fatal side effects, such as the risk of seizures, when used in conjunction with antidepressant drugs containing monoamine oxidase inhibitors (MAOi). MAOi is a contraindication in the use of tramadol. In other words, these two drugs should not be used together.
  • Increases the risk of seizures or serotonin syndrome if used in conjunction with Selective Serotonin Reuptake Inhibitors (SRRI), Serotonin-Norepinephrine Reuptake Inhibitors (SNRI), tricyclic antidepressants (TCA), and anticonvulsant drugs (eg bupropion, mirtazapine, and tetrahydrocannabinol).
  • Increases the antidepressant effect of norepinephrine, 5-HT agonists, or lithium, and increases the risk of bleeding if used in conjunction with coumarin derivatives, such as warfarin.
  • Carbamazepine can reduce tramadol levels in the blood.

Recognize the Side Effects and Dangers of Tramadol
Some of the common side effects after using Tramadol are:

  • Dizzy and confused.
  • Tired and sleepy.
  • Nausea and vomiting.
  • Constipation and difficulty urinating.
  • Dry mouth.
  • Bloated.
  • Diarrhea.

Under certain conditions, tramadol can cause serious side effects for children under the age of 17, such as difficulty breathing, breathing becomes slower, dazed, or has difficulty sleeping.


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