what is clozapine

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Clozapine is a drug used to reduce symptoms of psychosis. Psychosis is a condition where the sufferer cannot distinguish reality from fantasy. One of the symptoms of psychosis is hallucinations, namely hearing or seeing something that is not real. Symptoms of psychosis occur in people with schizophrenia, and sometimes can also occur in patients with Parkinson’s disease.

Clozapine works by balancing and suppressing the effects of chemical reactions that occur in the brain, thus helping to reduce the symptoms of psychosis


Trademarks: Clozapine, Clozaril, Clozer, Copine, Cycozam, Clorilex, Lozap, Nuzip, Sizoril

About Clozapine

Antipsychotic  Group
Prescription Drug Category
Benefits of reducing symptoms of psychosis
Consumed by adults

Category B pregnancy and breastfeeding

Category B: Studies in animal studies have not shown a risk to the fetus, but there have been no controlled studies in pregnant women. Clozapine can be absorbed into breast milk. Nursing mothers are not allowed to use this medicine.
Tablet Shape


  • Tell your doctor if you suffer from heart disease, vascular disorders, prostate gland disorders, liver disease, kidney disease, diabetes, epilepsy, glaucoma, depression, myasthenia gravis, respiratory disorders, tumors in the adrenal glands (pheochromocytoma), digestive disorders or have undergone intestinal surgery ,.
  • Tell the doctor about the medicines being consumed, including supplements and herbal products.
  • Clozapine can cause a decrease in the number of white blood cells, seizures, heart problems, and cardiac arrest.
  • Make sure the use of clozapine is always monitored by a doctor.
  • If an allergic reaction or overdose occurs after taking clozapine, see a doctor immediately.

Take Clozapine Properly
Follow the doctor’s advice and read the instructions printed on the drug packaging, in consuming clozapine.

This medicine can be consumed with or without food.

Try to consume clozapine at the same time every day, so that the maximum treatment results.

For patients who forget to take clozapine, it is advisable to do it immediately as soon as they remember, if the pause with the next consumption schedule is not too close. If it’s close, ignore it and don’t double the dose.

Follow the doctor’s recommendation to consume clozapine according to the allotted time. It is not allowed to stop taking clozapine suddenly because it can worsen the condition. The doctor will reduce the dose gradually, if it really needs to be stopped.

Store clozapine in a cool, dry place, and keep it away from sun exposure and reach of children.

Drug Interactions
The following are interactions that can occur when using clozapine along with other drugs:

  • Increase clozapine levels, if used with drugs containing caffeine, ciprofloxacin, or fluvoxamine.
    Reducing clozapine levels, if used with omeprazole.
  • Increases the risk of neuroleptic malignant syndrome which causes organ dysfunction and impaired consciousness, if used with lithium.
  • Decreases the concentration of phenytoin in the blood.
  • Increases the concentration of digoxin and warfarin in the blood.
  • Increases the risk of cessation of the respiratory system and heart, if used with benzodiazepine sedatives.
  • Risk of suppressing the bone marrow, if used with carbamazepine, chloramphenicol, cotrimoxazole, phenylbutazone, and penicillin. This results in a decrease in the production of blood cell counts.

Recognize Side Effects and Dangers of Clozapine
Clozapine can cause side effects in the form of disorders of the heart and blood cells, so patients need to be monitored through regular health checks. In addition, several other side effects that this drug can cause are:

  • Headache
  • Sleepy
  • Blurred vision
  • Dizzy
  • Nausea
  • Impaired urination
  • Constipation
  • The body feels hot and sweaty
  • Dry mouth, but saliva production increases
  • Your weight increases, but your appetite decreases
  • Tremor
  • Feel very tired
  • Hard to breathe.
  • Heart beat

Some of the side effects above will usually disappear by themselves, after the body adapts to the use of drugs. If the side effects don’t subside, see a doctor immediately.

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