Trihexyphenidyl – Benefits, dosage, side effects

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Trihexyphenidyl is used to treat extrapyramidal symptoms, both due to Parkinson’s disease or drug side effects, such as antipsychotics. Extrapyramidal symptoms include tremors, stiff bodies, abnormal and uncontrolled movements both on the face and other body parts, and anxiety.

Trademark: Arkine, Hexymer

About Trihexyphenidyl
Antimuscarinic drug group
Prescription Drug Category
Benefits Overcoming extrapyramidal symptoms
Consumed by adults

Categories of pregnancy and lactation
Category C: Studies in animal studies have shown adverse effects on the fetus, but there have been no controlled studies in pregnant women. The drug should only be used if the expected amount of benefit exceeds the risk to the fetus.

It is not yet known whether trihexyphenidyl can be absorbed into breast milk. However, this drug is not recommended for consumption by mothers who are breastfeeding.
Tablet form medicine


  • Please be careful of people with glaucoma, heart and blood vessel disease, liver disorders, kidney disorders, myasthenia gravis, prostate enlargement, and constipation.
  • Inform the doctor about medicines that are routinely consumed, including supplements and herbs.
  • Avoid consuming alcohol while using trihexyphenidyl because it can increase the effects of drowsiness.
  • If an allergic reaction or overdose occurs, see a doctor immediately.

Trihexyphenidyl dose

To treat extrapyramidal symptoms due to side effects of a drug, the initial dose is 1 mg per day. Furthermore, the dosage can be increased to 5-15 mg per day, which is divided into 3-4 consumption schedules.

Whereas in Parkinson’s disease, the initial dose is 1 mg per day, which can then be added 2 mg every 3-5 days, until it reaches a dose of 6-10 mg per day, which is divided into 3-4 consumption schedules.

Take Trihexyphenidyl correctly

Follow the doctor’s advice and read the information printed on the trihexyphenidyl package before using it.

Trihexyphenidyl is consumed best when eating, and try to consume it at the same time every day.

For those who forget to consume trihexyphenidyl, it is advisable to do it immediately as soon as they remember if pausing with the next consumption schedule is not too close. If it’s close, ignore it and don’t double the dose.

Make sure you see your doctor regularly during trihexyphenidyl so that your doctor can monitor the progress of your condition.

Store this medicine at room temperature, no need in the refrigerator.

Drug Interactions

The following are some of the risks that might occur if using trihexyphenidyl along with certain drugs, including:


  • Increases the risk of side effects if taken with clozapine and antihistamines.
  • Trihexyphenidyl can reduce the effects of domperidone and metoclopramide in the digestive tract.
  • Trihexyphenidyl can reduce the body’s ability to absorb levodopa.
  • Can cause mutually reinforcing effects when taken with tricyclic antidepressant drugs.

Recognize the Side Effects and Dangers of Trihexyphenidyl
Some of the side effects that might occur after taking trihexyphenidyl are:

  • Constipation.
  • Dizzy.
  • Difficulty urinating.
  • Dry mouth.
  • Blurry vision.
  • Nausea.

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