Orlistat – Benefits, dosage, side effects

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Orlistat is a drug used to treat overweight or obesity. Orlistat works by inhibiting enzymes that digest fat so that the fat eaten is not digested and is not absorbed into the body.

Orlistat is only used as a prescription drug recommended by doctors. Weight loss programs must be supported by the application of regular exercise and consumption of low-fat healthy foods because these drugs only counteract the absorption of fat as much as one-third of the portion of food consumed.

Trademarks: Slimax, Obeslim, Xenical

About Orlistat

Antiobesity Drug Group
Prescription Drug Category
Benefits of reducing fat absorption
Consumed by adults
Categories of pregnancy and lactation
Category X: Studies in experimental animals and humans have shown abnormalities in the fetus or risks to the fetus. Drugs in this category are contraindicated in women who are or are likely to become pregnant. It is not yet known whether orlistat can be absorbed into breast milk or not. However, breastfeeding mothers are advised not to take this medicine.
Capsule form


  • Orlistat may only be consumed by adult obese people (aged 18 years and over).
  • Tell your doctor if you suffer from bile duct disorders, impaired food absorption, diabetes, and impaired kidney function.
  • Avoid using this drug if you haven’t consumed nonfat foods. Especially if you haven’t eaten any food. This drug only reacts to foods that contain fat.
  • Orlistat can interfere with the performance of a number of drugs (especially contraceptive drugs), and block the absorption of vitamins A, D, E, and K. if taken together. Therefore, if you are going to consume orlistat along with other drugs or supplements, you should consult your doctor first.
  • If an allergic reaction or overdose occurs after taking orlistat, see a doctor immediately.

Orlistat dosage

Keep in mind, orlistat should only be consumed if prescribed by a doctor and for obese people aged 18 years and over.

Before using orlistat, it is recommended to measure body mass index (BMI) first. Orlistat is only recommended for obese sufferers who have a BMI value of 27 kg / m² or more.

The formula used in calculating BMI is body weight in kilograms divided by body height in meters squared (m²). For example, if a person’s weight is 66 kilograms and the height is 1.65 meters, then the calculation is 66 / (1.65 x 1.65) = 24.24 kg / m². If you still don’t understand about BMI calculation, ask your doctor.

For obese patients with a BMI of 27kg / m² or more, the dose of the drug is given 60-120 mg 3 times a day each mealtime per day. The dose will be stopped if obese people have reduced 5 percent of body weight within 12 weeks after taking the drug.

Eating Orlistat Correctly

In taking orlistat, follow the doctor’s advice and read the information printed on the drug packaging.

Orlistat capsules should be consumed with the help of water at meals or no later than 1 hour after meals. Ignore the consumption of drugs if you have not consumed any food or foods that contain fat. Orlistat only works if there is fat from food that enters the body.

Make sure there is enough time between one dose and the next. If you forget to take the medicine, ignore it and continue taking the drug as usual during the next meal. Do not double the orlistat dose on the next meal schedule to replace the missed dose.

The main treatment for obesity is lifestyle changes to be healthier. It is recommended to eat foods with excessive calories, reduce fat consumption, and fiber-rich foods, and exercise regularly.

Store orlistat in a cool, dry place, and avoid direct sunlight, and keep it out of reach of children.

Drug Interactions

The following are interactions that can occur when using orlistat together with other drugs:

  • Increases the risk of hypoglycemia, if given with diabetes medications.
  • Decreases absorption of levothyroxine, vitamins A, D, E, K, iodized salt, and beta carotene.
  • Reducing levels of amiodarone and ciclosporin in the blood.
  • Reducing the effectiveness of antiepileptic drugs (lamotrigine or valproate acid), antidepressants, antipsychotics, and antivirals.
  • Increases the risk of bleeding, if used with warfarin.
  • Reducing the effectiveness of birth control pills.

Recognize the Side Effects and Dangers of Orlistat

Side effects that may arise after consuming orlistat are:

  • Headache
  • Anxiety
  • The menstrual cycle is interrupted
  • Abdominal pain
  • Discomfort in the lower abdomen
  • Increased frequency of defecation and difficulty in holding it back.
  • Oily stool texture
  • Throat infection
  • Lung infection

Stop using the drug and immediately see a doctor if orlistat causes a serious allergic reaction, swelling under the skin layer (angioedema), lack of vitamins A, D, E, K, and symptoms of liver dysfunction such as decreased appetite, jaundice, itching- itching, dark urine, pale stools, or abdominal pain in the upper right.

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