Codeine – Benefits, dosage, side effects

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Codeine is an opioid analgesic drug used to relieve mild to severe pain. This drug works directly on the central nervous system to reduce the pain experienced. In certain cases, codeine can also be used to relieve cough symptoms and treat acute diarrhea conditions.

Codeine can trigger dependence if it is not consumed according to the doctor’s recommendations. Make sure you don’t add a dose or stop treatment suddenly to avoid drug withdrawal symptoms or other dangerous side effects, such as shortness of breath, overdose, or death.

Trademark: Codikaf, Codipront, Coditam

About Codeine

Group of opioid analgesics
Prescription Drug Category

  • Relieves mild to severe pain
  • Relieve cough symptoms
  • Treat acute diarrhea conditions

Used by adults and children over 12 years

Categories of pregnancy and lactation
Category C: Studies in animal studies have shown adverse effects on the fetus, but there have been no controlled studies in pregnant women. Medicines should only be used if the expected benefits outweigh the risks to the fetus. Category D (for long-term use): There is positive evidence about the risk to the human fetus, but the number of benefits obtained may be greater than the risk, for example, to overcome a threatening situation soul.
Tablet and injection form


  • Avoid consuming codeine if you suffer from respiratory problems, such as asthma or hyperventilation, or if you have a blockage in the intestine or stomach.
  • Watch out for users who have kidney disease, liver disease, chronic obstructive pulmonary disease (COPD), sleep apnea, hypertension, head trauma, have brain tumors, mental disorders, pancreatic abnormalities, swelling of the prostate, difficulty urinating, myasthenia gravis, adrenal gland disorders (eg Addison’s disease), or thyroid disorders.
  • Tell your doctor if you are or have had a drug or alcohol dependence, are taking sedatives like diazepam, or are on medication for depression, Parkinson’s disease, dizziness and migraines, serious infections, or nausea and vomiting.
  • For children under the age of 18 who have recently undergone tonsillectomy or lymph nodes (adenoid), it is recommended not to consume codeine, unless instructed by a doctor.
  • If an allergic reaction or overdose occurs after using codeine, see a doctor immediately.

Codeine dosage

The doctor will adjust the codeine dose to the condition and patient response to this treatment. The following are the dosages that are generally recommended for codeine oral forms or tablets:


Mild to severe pain
Adults: 15-60 mg every 4 hours. The maximum dose per day is 360 mg. Children over 12 years: 0.5-1 mg / kg given every 4 or 6 hours. The maximum dose per day is 240 mg.

Cough symptoms
Adults: 15-30 mg every 3-4 hours. Children: 3 mg for children aged 2-5 years, and 7.5-15 mg for children aged 6-12 years. The dosage is generally given every 3-4 hours.

Acute diarrhea
Adults: 15-60 mg every 3-4 hours.

For those who need treatment using injectable injections, the dosage will be adjusted by the doctor with the condition of the patient in the hospital.

Using Codeine Correctly

Follow the doctor’s advice on consuming codeine. This medicine can be taken before or after meals. Swallow medicine directly using water. If you feel nauseous, the medicine can be taken with the help of milk or during meals.

Make sure you drink 8 glasses of water every day while undergoing treatment with codeine to avoid constipation.

Take codeine according to the dosage given by the doctor. Do not add or reduce doses without consulting first because they have the potential to trigger dangerous side effects, such as withdrawal symptoms until an overdose.

It is recommended not to consume alcohol while undergoing this treatment to avoid side effects.

Codeine can cause drowsiness and dizziness. It is recommended not to drive or operate heavy equipment after taking this medicine.

If you forget to consume codeine, it is recommended to do it immediately if paused with the next consumption schedule not too close. If it’s close, ignore it and don’t double the dose.

Drug Interactions

The following are some of the risks that might occur if you use codeine along with certain drugs, including:

  • It can cause potentially fatal additional effects if taken together with a monoamine oxidase inhibitor (MAOI) enzyme inhibitor.
  • Increases the depressant effect when used with anesthetic drugs, trichloroacetic acid (TCA), anxiolytics, hypnotics, and antipsychotics.
  • It can change the composition effects of other compounds such as mexiletine, metoclopramide, and domperidone.

Recognize the Side Effects and Dangers of Codeine

Here are some side effects that can be felt after consuming Codeine:

  • Dizzy, confused.
  • Dry mouth.
  • Nausea and vomiting.
  • Loss of appetite.
  • Easy to feel tired.
  • Constipation.
  • Feeling pain in the stomach.
  • A mild rash appears on the skin.

See a doctor immediately if you experience the following side effects after using codeine:

  • Fever.
  • Cheerful or trembling.
  • Hard to sleep.
  • Irregular heartbeat.
  • Short or irregular breath.
  • Unreasonably sweating.
  • Yellow skin or eyes.
  • Blurry or double vision.
  • Changes in behavior.
  • Convulsions.
  • Disorders of the menstrual cycle.
  • Impotence or infertility.
  • Fainted.

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